Perfluorocarbons Enhance a T2*-Based MRI Technique for Identifying the Penumbra in a Rat Model of Acute Ischemic Stroke
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15 صفحه اولImaging the ischemic penumbra with 18F-fluoromisonidazole in a rat model of ischemic stroke.
BACKGROUND AND PURPOSE The ischemic penumbra is a major focus of stroke research. 18F-fluoromisonidazole (18F-FMISO), a positron emission tomography (PET) marker of hypoxic cells, has shown promise as a technique to image the penumbra in humans. Our aim was to delineate the pattern of 18F-FMISO binding in a rat middle cerebral artery transient thread-occlusion model, and correlate this with tis...
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Introduction: Ischemic stroke is the leading cause of morbidity and the third most common cause of mortality in USA. The identification of the culprit thrombotic lesion, micro-emboli and the source of the embolus are all critical to patient management. EP2104R [1], a fibrin-specific molecular MR agent, was previously shown to enhance arterial and venous thrombi in large animal models (swine, ra...
متن کاملSodium MRI of Core and Penumbra in ischemic stroke patients
Background and Purpose: Diffusionand perfusion-weighted imaging (DWI/PWI) of acute ischemic stroke can be used to identify the ischemic core (DWI) and to estimate the penumbral tissue (PWI-DWI mismatch) which is at risk of infarction but is potentially salvageable. MRI of sodium, a marker of ionic homeostasis that is disrupted after ischemia, within the lesion may be complementary by indicating...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2013
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2013.86